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Intracellular Bacterial Vaccine Vectors: Immunology, Cell Biology, and Genetics

Intracellular Bacterial Vaccine Vectors Immunology Cell Biology and Genetics

Host defense against infectious microorganisms is becoming an intensively studied topic recent advances in immunology and microbiology have resulted in a substantially improved understanding of the pathways used by a variety of microorganisms to infect humans br br This resource provides up to date reviews of the invasion strategies utilized by selected bacteria and then shows how these microorganisms can be manipulated to generate potential vaccines The book begins with a comprehensive review of the relationship between bacterial life styles and immune responsiveness to bacterial antigens The book is divided into two parts Part describes basic research intended primarily for academic scientists Included in this section are chapters describing the use of Listeria monocytogenes Salmonella typhimurium and Bacillus Calmette Guerin BCG to invoke different types of immune response Part describes the application of the engineered Listeria monocytogenes as a vaccine against specific tumors and the use of recombinant Salmonella and BCG in clinical trials for HIV and TB

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